TY - JOUR T1 - Investigation of survivin gene expression in non small cell lung cancer JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - P2710 AU - Engin Aynaci AU - Sadettin Kamat AU - Yasemin Müsteri Oltulu AU - Pinar Yildiz AU - Ender Coskunpinar AU - Neslihan Akanil AU - Onur Kum AU - Ilhan Yaylim Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/P2710.abstract N2 - The survivin gene is located on human chromosome 17q25 which is composed of 142 amino acids. Survivin is one of the first reported inhibitors of apoptosis proteins (IAPs), which is an important family of proteins that regulate apoptosis. Survivin gene expression aberration providing a sensitivity for the development of lung cancer. A common polymorphism on the survivin gene promoter (-31G/C) has been shown to influence the survivin expression and the risk of cancer development. The genetic variant -31G/C on the survivin promoter region has been identified to be associated with overexpression of survivin at both protein and mRNA levels in cancer cells. The overexpression of survivin was found to be associated with disease development, recurrence and prognosis in various malignancies, including cancers. In this study the demonstration of the prognosis related associations between surviving gene expression and non small cell lung cancer (NSCLC) was aimed. There were 27 surgically operated NSCLC patients included to the studyView this table:Nucleolar survivin expression. Immunohistochemical staining technique was used as the method. According to the survivin gene expression analysis no statistically significant difference were foundView this table:Cytoplasmic survivin expression. ER -