RT Journal Article
SR Electronic
T1 Bodyplethysmography during bronchoconstriction induced by inhaled histamine
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P1827
VO 44
IS Suppl 58
A1 Wilmy Alings-Bokkestijn
A1 Babette Groen-Kingma
A1 Peter Van Tilburg
A1 Jan-Maarten Van Haarst
A1 Selma De Nijs
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/P1827.abstract
AB Introduction: According to the guidelines [Sterk, ERJ 1993] FEV1 is the first choice lungfunction measurement to assess airway hyperresponsiveness. However, in some patients measuring FEV1 is not possible as a result of inadequate technique or can be to strenuous. To that end, measuring airway resistance is preferred but has never been validated.Aim: To investigate the relationship between airway resistance changes (Rtot), intrathoracle gasvolume (ITGV) changes and FEV1 during bronchoconstriction induced by histamine in patients with symptoms suggestive for asthmaMethods: In 33 patients (mean ± SD) age:51±16.3, %pred FEV1 105±12.1 with symptoms suggestive for asthma were challenged with histamine. FEV1 and bodyplethysmography (for assessment Rtot, ITGV), were measured before the test and after each administration of histamine to achieve a greater than 20% fall in FEV1. Response dose ratios were calculated as the %fall in FEV1 or % increase Rtot and IGTV, divided by the total mg of histamine administered. Correlations were calculated using spearman's correlation test.Results: 19 out of 33 patients showed airway hyperresponsiveness to inhaled histamine (≤20% fall in FEV1). There was a significant correlation between RDR FEV1/Histamine and RDR SGAW/histamine (r=0.78,p=<0.001). In addition, a correlation between RDR ITGV/histamine (r=0.59, p<0.001) was found.Conclusion: In patients with symptoms suggestive for asthma there is a relationship between specific airway resistance changes and FEV1 during bronchoconstriction induced by inhaled histamine. These data suggest that specific airway resistance could be used but needs to be standardised according international guidelines.