RT Journal Article SR Electronic T1 Impacts of long-term CPAP therapy on fatty liver in male OSA patients with abdominal obesity JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP 4661 VO 44 IS Suppl 58 A1 Yoshiro Toyama A1 Kimihiko Murase A1 Masanori Azuma A1 Satoshi Hamada A1 Ryo Tachikawa A1 Takeshi Kubo A1 Kiminobu Tanizawa A1 Morito Inouch A1 Tomohiro Handa A1 Takefumi Hitomi A1 Toru Oga A1 Michiaki Mishima A1 Kazuo Chin YR 2014 UL http://erj.ersjournals.com/content/44/Suppl_58/4661.abstract AB Background: The evidences for significant relationships between obstructive sleep apnoea (OSA) and fatty liver is gradually accumulating. However, placebo-controlled studies in OSA patients with mild fatty liver reported that several months of continuous positive airway pressure (CPAP) therapy did not improve fatty liver. On the other hand, the strong causal factor of fatty liver is abdominal obesity, the central factor of metabolic syndrome. The aim of this study is to evaluate the changes in liver fat accumulation (LFA) of OSA patients with abdominal obesity and developed fatty liver after longer-term CPAP therapy.Methods: The participants were 61 male OSA patients who had started CPAP between 2008 and 2010 and had abdominal obesity (waist circumference ≥ 85 cm; Japanese criterion) at the time. At the follow-up examination, the data from abdominal computed tomography (CT), fasting blood tests and CPAP memory cards were collected. LFA was determined as an average CT value of liver. Visceral fat accumulation and subcutaneous fat accumulation were also measured.Results: The average age, BMI and LFA at the baseline, and the average period and daily usage time of CPAP were 57.2 y, 28.6 kg/m2, 49.7 HU, 31.3 M, and 4.8 h/d, respectively. In the entire group, LFA did not change during the CPAP therapy. On the other hand, in those who had developed fatty liver (CT value of liver < 50 HU) at the baseline, LFA decreased after the CPAP in spite of stable BMI, visceral and subcutaneous fat accumulation, and other metabolic conditions.Conclusion: Long-term CPAP may contribute to improvement of fatty liver in OSA patients with abdominal obesity and developed fatty liver.