PT  - JOURNAL ARTICLE
AU  - Ahmet Hakan Gedik
AU  - Erkan Cakir
AU  - Yasemin Gokdemir
AU  - Zeynep Seda Uyan
AU  - Abdurrahim Kocyigit
AU  - Emel Torun
AU  - Bulent Karadag
AU  - Refika Ersu
AU  - Fazilet Karakoc
TI  - Total oxidative stress, total antioxidant status and paraoxanase activity in pediatric patients with bronchiolitis obliterans
DP  - 2014 Sep 01
TA  - European Respiratory Journal
PG  - P1232
VI  - 44
IP  - Suppl 58
4099  - http://erj.ersjournals.com/content/44/Suppl_58/P1232.short
4100  - http://erj.ersjournals.com/content/44/Suppl_58/P1232.full
SO  - Eur Respir J2014 Sep 01; 44
AB  - Introduction and Aim: Oxidants are normal part of cell metabolism and important in cell hemostasis. Airway mucosa developed antioxidant system to protect itself from harmful oxidants. Imbalance between these systems may caused cell damage. Paraoxonase (PON), is an antioxidizing enzyme, increased with diseases characterized by high oxidative stress. Oxidative stress is supposedly down-regulates serum PON1 expression. We aim to determine total oxidative stress (TOS), total antioxidant status (TAS) and PON levels and compare with control group in pediatric Bronchiolitis Obliterans (BO) patients. Method: The patients between 0-16 years-old was admitted between 2012-2013 september and age and gender matched healthy controls were enrolled in the multi-center study. Serum TOS, TAS, and PON levels were determined with ELISA method and compared with control group. Findings: Sixty-three BO patients, sixty-seven percent of them were male, enrolled in the study. Median age was 74±58 months. Sixty-five children included to the study as control group and age and gender distribution were not statistically different between the two groups (p>0,05). TAS, TOS, and PON levels were significantly higher in BO group compared with healthy controls (p=0.01, p=0.011, p<0.001, respectively). Conclusion: This is the first study about TAS, TOS, and PON levels in pediatric post-infectious BO patients. According to preliminary report, TAS levels were significantly lower in BO patients. Oxidant and antioxidant system may have important role in immune pathogenesis of BO patients.