PT - JOURNAL ARTICLE AU - Usman Farkhutdinov AU - Albert Mirchaidarov AU - Rafagat Farkhutdinov TI - Importance of immunostimulation for community acquired pneumonia management DP - 2014 Sep 01 TA - European Respiratory Journal PG - P1045 VI - 44 IP - Suppl 58 4099 - http://erj.ersjournals.com/content/44/Suppl_58/P1045.short 4100 - http://erj.ersjournals.com/content/44/Suppl_58/P1045.full SO - Eur Respir J2014 Sep 01; 44 AB - Active oxygen forms (AOF) play an important role in pathogenesis of lung diseases. Excessive generation of AOF may be one of the reasons of immunity disorders in patients with community acquired pneumonia (CAP).The aim was to study the effect of i.v. immunoglobulin immunovenin (IMV) administration to patients with CAP.Methods:The study included 35 patients with CAP. Generation of AOF in blood of patients was studied by luminol-dependent chemiluminescence (ChL) registration. The patients blood was tested to estimate the level of CD3+, CD4+, CD8+, CD16+, CD20+ lymphocytes, the content of A,G,M immunoglobulins (Ig), circulating immunocomplexes (CIC), γ-IFN and TNFa. 17 patients were treated with standard therapy. 18 patients received combined treatment with IMV.Results: ChL intensity of blood in patients was higher by 2.8 times. It indicated increased production of AOF by blood cells. The level of CD3+,CD4+,CD8+, CD16+ lymphocytes was lower by 1.6-1.8 times, the content of IgA, IgG was lower by 1.3 times and the level of γ-IFN was lower by 2.0 times. Conversely, the level of CD20+ lymphocytes, IgM, CIC and TNFa were higher by 1.6 times. The use of IMV has decreased generation of AOF in blood, eliminated immune disorders, resulted in positive dynamics of clinical findings. With the use of standard therapy high ChL intensity of blood and impairment of the immune status persisted for a long time, the inflammatory process acquired a protracted pattern.Conclusion: In patients with CAP immunovenin improved AOF production and the immunity status, increased the treatment efficacy.