@article {Campman4832, author = {Carlijn Campman and Dirk van Ranst and Jan-Willem Meijer and Margriet Sitskoorn}, title = {Screening for cognitive impairment in patients with COPD}, volume = {44}, number = {Suppl 58}, elocation-id = {4832}, year = {2014}, publisher = {European Respiratory Society}, abstract = {Background: Cognitive impairments in patients with COPD have been associated with decreased treatment adherence, impaired daily functioning, and more hospitalizations. Screening for cognitive impairment can identify patients at risk for those negative outcomes. [CNS Vital Signs(CNS)] is a computerized cognitive screening instrument that can be useful in clinical practice of COPD patients. It measures multiple cognitive domains in 30 minutes and automatically generates a report of the patient{\textquoteright}s results compared to age-matched normative data. Here we present results of this instrument in patients with COPD.Methods: 247 COPD patients(123 males;age:61.5{\textpm}8.5;years of education:10.5{\textpm}3.0;GOLD-3/4:41/43\%) completed [CNS] prior to pulmonary rehabilitation at Schoondonck, Breda, Netherlands. Scores were transformed into age-corrected Standard Scores(SS) and compared with the mean SS(100) of normative data of healthy people. An SS lower than 80(1.5 SD) was considered impaired.Results: Except Reaction Time, mean performance of COPD patients was significantly worse than the norm on Psychomotor Speed(p\<0.001), Complex Attention(p\<0.001), Cognitive Flexibility(p\<0.001), Processing Speed(p\<0.001), Executive Functioning(p\<0.001), Verbal Memory(p\<0.001), and Visual Memory(p\<0.001). 56.3\% of the patients showed impaired performance on 1 or more cognitive domains. The highest rates of impairment were found on Processing Speed (27.5\%), Cognitive Flexibility(22.1\%), Complex Attention(21.7\%), and Verbal Memory(20.8\%).Discussion: A substantial part of the patients showed cognitive impairments, while 43.7\% of the patients scored within the normal range. Further analyses will focus on patient characteristics that predict cognitive impairment.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/44/Suppl_58/4832}, eprint = {https://erj.ersjournals.com/content}, journal = {European Respiratory Journal} }