RT Journal Article
SR Electronic
T1 The dynamic changes of amino acid expression profiles in patients with sepsis
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P2080
VO 44
IS Suppl 58
A1 Longxiang Su
A1 Hua Li
A1 Aimei Xie
A1 Kun Xiao
A1 Xin Li
A1 Lixin Xie
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/P2080.abstract
AB Introduction:The metabolic disorders of critical illnesses are highly complex. Objectives:The goal of this work was to explore the dynamic expression profiles of amino acids relates to sepsis patients with the aim of providing guidance for clinical nutrition support therapies. Methods:This study included 35 critically ill patients with sepsis, who were further divided into sepsis (12 cases) and severe sepsis (23 cases) or, alternatively, survivors (20 cases) and non-survivors (15 cases). 14 SIRS patients and 18 health control were also included. The serum samples of the patients were collected on days 1, 3, 5, 7, 10, and 14 following ICU admission, and the expression of 42 amino acids was monitored using a liquid chromatography-mass spectrometry method. Results:The metabolism spectrum of the amino acids changed dramatically in patients with sepsis. As the disease progressed further or upon death, the expression levels of different amino acids with time either showed a gradual increase, decrease, or fluctuation in the expression levels. The concentrations of sulfur-containing amino acids, especially taurine, decreased significantly as the severity of sepsis worsened or upon death of the patient. The serum concentrations of the sulfur-containing amino acids and taurine exhibited a weak negative correlation with the SOFA (r=-0.319) and APACHE II (r=-0.325) scores. Conclusions:This study suggested that critically ill patients with disorders of amino acid metabolism, especially sulfur-containing amino acids and taurine. Higher APACHE II and SOFA scores were associated with lower levels of sulfur-containing amino acids and taurine during sepsis. This study may provide the basis for sepsis nutritional support.