%0 Journal Article %A Valerie Siao %A Julie Mulliez %A Xavier Drouot %A Michel Eugene %A Veronique Diaz %T Analyse of the MEFV curve in preschool children by measurement of expiratory volume in the course of expiratory flow %D 2014 %J European Respiratory Journal %P P1147 %V 44 %N Suppl 58 %X In preschool children, a reliable performance of spirometry is rarely be obtained by standard lung function test. The airway obstruction is evaluated with the measurement of respiratory system resistance by interruption and impulse oscillation test. Nevertheless, maximum expiratory flow volume (MEFV) curves offer more information on airway caliber than resistance measurements. The aim of our study was to analyse the MEFV curve in preschool children with and without airway obstruction by measuring the expiratory volume in the course of expiratory flow and to compare standard forced expiratory test ( FEV1, MEF25, MEF50, MEF75) with expiratoy volume (Vexp30, Vexp60, Vexp90) at 30%, 60% and 90% of PEF.Primary, retrospectively, we analysed Vexp 30, Vexp60 and Vexp90 in asthmatic and control school aged children. Then, we compared Vexp and resistance measurement by interruption in asthmatic and control preschool children.In the retrospective part of the study, 26 asthmatic school-aged children and 32 control were included. Vexp 30, Vexp60 and Vexp90 were significantly lower in the asthmatic group (p<0.05). Vexp30, Vexp60, Vexp90 were higher after reversibility test with inhaled bronchodilatator. In the prospective part, all of the 55 preschool children have done the MEFV curves with no difficulty.Vexp 90 and Vexp60 were lower in the asthmatic group ( p<0.05).Airway obstruction evaluation is very important in asthma management of the preschool children: it is predictive of the severity of asthma and predictive of lung function in adulthood. We will compare the Vexp in healthy and asthmatic preschool children in a largest study to obtain reference values. %U