TY - JOUR T1 - Short-term effects of surfactant administration on regional lung function in a model of ventilator-induced lung injury (VILI) in rabbit JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - 4435 AU - Sam Bayat AU - Gergely Albu AU - Liisa Porra AU - Iliona Malaspinas AU - Camille Doras AU - Ferenc Peták AU - Walid Habre Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/4435.abstract N2 - Goals: We asessed the changes in regional lung function following instillation of surfactant in VILI induced by whole lung lavage followed by mechanical ventilation.Methods: Regional specific ventilation (sV'), was measured using K-edge subtraction synchrotron CT imaging during xenon washin, in 8 anaesthetized, paralyzed, New-Zealand White rabbits. Lung regions were classified as poorly-aerated (PA), normally aerated (NA) or hyperinflated (HI) based on regional density. A functional category was defined within each class, based on sV' distribution (High, Normal, Low). Airway resistance (Raw), respiratory tissue damping (G) and elastance (H) were measured by forced oscillation technique (FOT) at low frequencies before and after lavage (100 ml/kg), immediately and 30 minutes after intratracheal instillation of 70 mg/kg of surfactant.Results: Surfactant improved Raw, G and H (p<0.05, each) compared to lavage and significantly increased poorly aerated regions with high sV' (p<0.001). This was partly due to a reduction in atelectasis (p<0.001), but also to decreased aeration in previously normally-aerated regions with high sV' (p=0.013) (Figure).Conclusions: Although surfactant treatment improved central airway and tissue mechanics and atelectasis in this model of lung injury, it deteriorated regional lung function in regions where local aeration was normal prior to administration. ER -