RT Journal Article SR Electronic T1 Cardiac MRI derived right ventriculo-arterial coupling in pulmonary hypertension as a predictor of survival JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP P2300 VO 44 IS Suppl 58 A1 Melanie Brewis A1 Robert Naeije A1 Alessandro Bellofiore A1 Naomi Chesler A1 Andrew Peacock YR 2014 UL http://erj.ersjournals.com/content/44/Suppl_58/P2300.abstract AB It is possible to estimate right ventriculo-arterial (VA) coupling using cardiac MRI (CMR) derived stroke volume (SV) and end systolic volume (ESV) as the ratio (SV/ESV). SV/ESV is equivalent to a ratio of elastances with a common pressure, and in principle is preload independent.Methods: 121 group 1 treatment naïve pulmonary hypertension (PH) patients underwent CMR at diagnosis. 46 underwent repeat CMR after minimum of 3 months of therapy.Results: SV/ESV was predictive of survival (P=0.001, table1), but did not improve significantly with therapy (table2).Conclusion: SV/ESV predicts survival in PH, but does not seem to provide added value over ejection fraction (RVEF) and does not change with specific treatment. Correlation with invasive data is needed to assess if SV/ESV is an accurate reflection of VA coupling.Table1: Age and gender adjusted survival predictors. Abbreviations RVEDVI right ventricular (RV) end diastolic volume index; RVESVI RV end systolic volume index; LVEDVI left ventricular end diastolic volume indexTable2: baseline and follow up CMR variables after minimum of 3 months of therapy (mean ±SD or median (IQR)).