TY - JOUR T1 - Antimicrobial peptides cathelicidin (LL-37) ve human β2 defensin levels of pediatric patients with bronchiolitis obliterans JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - P1231 AU - Ahmet Hakan Gedik AU - Erkan Cakir AU - Yasemin Gokdemir AU - Zeynep Seda Uyan AU - Abdurrahim Kocyigit AU - Emel Torun AU - Bulent Karadag AU - Refika Ersu AU - Fazilet Karakoc AU - Ahmet Hakan Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/P1231.abstract N2 - Introduction: Antimikrobial peptides (AMP) are one of the most important component of innate immune system and have important role in many respiratory disease. No data is available in the literature about the levels of AMP in pediatric patients with bronchiolitis obliterans. Aim: To determine cathelicidin and defensin levels and compare between BO patients and control group. Method: The patients between 0-16 years-old was admitted between 2012-2013 september and age and gender matched healthy controls were enrolled in the multi-center study. Serum cathelicidin (LL37) ve β2 defensin levels were determined with ELISA method. Findings: Sixty-three BO patients, sixty-seven percent of them were male, enrolled in the study. Median age was 74±58 months. Sixty-five children included to the study as control group and age and gender distribution were not statistically different between the two groups (p>0,05). Cathelicidin and β2 defensin levels were significantly higher in BO group compared with healthy controls (p<0.001). Conclusion: This is the first study about AMP levels of pediatric BO patients. Cathelicidin and β2 defensinlevels were significantly higher in pediatric BO patients. AMP may have important roles in immune systems of pediatric BO patients. ER -