PT  - JOURNAL ARTICLE
AU  - Yuji Kusunoki
AU  - Kumiko Hattori
AU  - Toshie Nakamura
AU  - Takashi Motegi
AU  - Takeo Ishii
AU  - Ryuko Furutate
AU  - Akihiko Genma
AU  - Kozui Kida
TI  - Increased frequency of supraventricular (SVPC) and ventricular arrhythmias (PVC) in stable patients with chronic obstructive pulmonary disease (COPD)
DP  - 2014 Sep 01
TA  - European Respiratory Journal
PG  - P1466
VI  - 44
IP  - Suppl 58
4099  - http://erj.ersjournals.com/content/44/Suppl_58/P1466.short
4100  - http://erj.ersjournals.com/content/44/Suppl_58/P1466.full
SO  - Eur Respir J2014 Sep 01; 44
AB  - Background: Clinical significance of both SVPC and PVC in COPD is noteworthy in therapy.Aim: We investigated the association between frequency of SVPC and PVC, and pulmonary function, exercise capacity and emphysema severity on chest computed-tomography (LAA%).Methods: Stable COPD or symptomatic patients (n=135) recruited who had arrhythmia on a 12-lead ECG or chest symptoms such as palpitation. The patients (n=103, men 90, mean age 68.8 years), excluded receiving anti-arrhythmia medications, underwent pulmonary function tests, 24 hr-ECG, echocardiogram, LAA% and 6 minutes walking test (6MWT).Results: 24-hour heart rate increased with FEV1%pred (r=-0.337, p<0.001). Both frequency of SVPC and PVC were significantly associated with severity of airflow obstruction; the SVPC and PVC for FEV1%pred (odds ratio 1.030, 95%CI 1.01-1.05, p<0.001) and (1.036, 1.01-1.05, p<0.000), respectively. The frequency of PVC increased with LAA% (0.957, 0.92-0.98, p<0.003), pressure of right ventricle (0.917, 0.85-0.97, p<0.003) and nadir oxygen saturation in 6MWT (1.114, 1.03-1.21, p<0.006). Whereas, the frequency of SVPC increased with LAA% (0.971, 0.94-0.99, p<0.03). The frequency of SVPC was significantly associated with taking medications, including anti-cholinergic (0.286, 0.12-0.64, p<0.003),β2 agonist (0.267, 0.10-0.63, p<0.003) and theophylline (0.208, 0.06-0.60, p<0.004), respectively, but not with PVC.Conclusions: Frequency of SVPC and PVC increases with severity of COPD. Increased of PVC frequency is affected by right ventricular pressure and hypoxemia on exertion. And increased of SVPC frequency is affected by use of bronchodilators.