RT Journal Article
SR Electronic
T1 Elevated exhaled NO is a predictor of exercise-induced bronchoconstriction in adolescents
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P1005
VO 44
IS Suppl 58
A1 Henrik Johansson
A1 Christer Janson
A1 Katarina Norlander
A1 Kjell Alving
A1 Leif Nordang
A1 Lennart Nordvall
A1 Andrei Malinovschi
A1 Margareta Emtner
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/P1005.abstract
AB Exhaled nitric oxide (FeNO) is a marker of airway inflammation in asthma and high FeNO levels can predict later onset of asthma in healthy children. Elevated FeNO relates to bronchial responsiveness to mannitol in population-based studies of young adults, but the relation to exercise-induced bronchoconstriction (EIB) has been limitedly studied in such a setting.FeNO measurement and standardized exercise challenge test were performed in 128 adolescents, 13-16 years, representing a subsample from a population-based study analyzing prevalence of exercise-induced dyspnea. Subjects with current asthma were excluded.Subjects with EIB (FEV1-fall ≥10%) (n=39) had higher FeNO than subjects without EIB (n=89); 17.0 ppb (CI 13.4, 21.4) vs. 13.0 (CI 11.5, 14.6), p=0.03. Subjects with EIB were characterized by being more likely to report exercise-induced dyspnea, to have a FeNO>20 ppb, a lower pre-exercise FEV1 and having a trend towards comprising a higher proportion of females and subjects with ever asthma (Table 1). High FeNO (>20 ppb) (OR 3.6 (1.3, 10.1)), exercise-induced dyspnea (OR 3.6 (1.2, 10.8)) and female gender (OR 3.1 (1.1, 9.1)) were independent predictors of EIB in a multiple logistic regression model, adjusted for variables in Table 1.In conclusion, elevated FeNO, exercise-induced dyspnea and female gender were independently related to EIB in adolescents.View this table:Table 1