PT  - JOURNAL ARTICLE
AU  - Bertram Jobst
AU  - Simon Triphan
AU  - Oliver Sedlaczek
AU  - Angela Anjorin
AU  - Hans-Ulrich Kauczor
AU  - Jürgen Biederer
AU  - Julia Ley-Zaporozhan
AU  - Sebastian Ley
AU  - Mark Wielpütz
TI  - Functional lung MRI in COPD: Comparative assessment of T1 mapping, oxygen-enhanced T1 mapping and perfusion MRI at 1.5 Tesla
DP  - 2014 Sep 01
TA  - European Respiratory Journal
PG  - 1723
VI  - 44
IP  - Suppl 58
4099  - http://erj.ersjournals.com/content/44/Suppl_58/1723.short
4100  - http://erj.ersjournals.com/content/44/Suppl_58/1723.full
SO  - Eur Respir J2014 Sep 01; 44
AB  - Objectives:Lung function testing provides limited information on regional lung characteristics. Therefore, alternative endpoints for interventional trials are pivotal. T1 relaxation times in lung MRI are known to depend on tissue composition including the blood volume fraction. The aim of this study was to validate T1 mapping and oxygen-enhanced (OE) T1 mapping against first-pass perfusion MRI in COPD patients.Methods:20 COPD patients (GOLD I-IV) underwent MRI, comprising of a coronal 2-dimensional inversion recovery snapshot flash sequence (8 slices/lung) at room-air and after supplementing pure oxygen, as well as perfusion imaging with high temporal resolution (1.5 s per lung) at room-air. The spatial extent of abnormal T1 at room-air (T1RA), restricted oxygen-induced T1 shortening (ΔT1) and perfusion deficits were rated by 2 chest radiologists in consensus using a semi-quantitative 3-point scale in a zone-based approach.Results:T1RA correlated positively with the extent of perfusion deficits (r=0.81; p<0.001). ΔT1also correlated positively with perfusion deficits (r=0.80; p<0.001) and T1RA (r=0.80; p<0.001). Interestingly, in GOLD stages I&II ΔT1 was normal in 16/39 lung zones with perfusion impairment. In a per-patient approach perfusion impairment (r=0.52; p<0.05), T1RA (r=0.45; p<0.05), and ΔT1 (r=0.52; p<0.05) showed a moderate correlation with GOLD stage.Conclusion:T1 mapping and OE T1 mapping corresponded well with perfusion MRI and GOLD stage, and provide complementary information about blood volume distribution in COPD. In particular, OE T1 mapping contributes to the differentiation of hypoxic vasoconstriction and genuine perfusion impairment.