RT Journal Article
SR Electronic
T1 Prevalence of COPD in a sub-Saharan country: Fresh Air Uganda survey
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 4414
VO 44
IS Suppl 58
A1 Frederik van Gemert
A1 Bruce Kirenga
A1 Niels Chavannes
A1 Moses Kamya
A1 Simon Luzige
A1 Patrick Musinguzi
A1 Rupert Jones
A1 Ioanna Tsiligianni
A1 Sian Williams
A1 Corina de Jong
A1 Thys van der Molen
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/4414.abstract
AB AimTo collect data on prevalence of COPD and related risk factors in a rural area of Uganda.MethodsPopulation-based cross-sectional epidemiological survey of randomly selected subjects above age of 30. Trained local healthcare workers used validated questionnaires, and performed pre- and post-bronchodilator spirometry. The lower limit of normal threshold, i.e. below the fifth percentile of the predicted FEV1/FVC ratio, was used as defining criterion of COPD.ResultsSubjects (n=588) mean age: 45 (SD ± 13.7), 50.5% women; 93% exposed to indoor biomass smoke (men: 91%, mean 3.1 hours/day; women: 95%, mean 5.2 hours/day); 94% used kerosene lamps. The prevalence of COPD was 16.2% (53% women): 78% GOLD 1, 20% GOLD 2, and 2% GOLD 3. Prevalence was highest in group 30-39 years: 38% of men and 40% of women.In the COPD group, men 44% current and 24% former smokers; women 8% current and 18% former smokers. Total mean Clinical COPD Questionnaire (CCQ) 0.81 (SD ± 0.78) and MRC dyspnoea score 1.33 (SD ± 0.65); 30% had one or more exacerbations during last 12 months, increasing with age.In multiple regression analyses, only a few factors were found to be associated with COPD: wheeze OR 2.19 (95%CI: 1.09-4.37;p=0.026), cough OR 1.64 (95%CI: 0.96-2.78;p=0.068), heart failure OR 2.53 (95%CI: 0.99-6.50;p=0.054), current smoker OR 1.65 (95%CI: 0.95-2.88;p=0.078), and former smoker OR 1.93 (95%CI: 1.05-3.52;p=0.033).ConclusionIn Uganda, the prevalence of COPD is high, especially in lower age groups. In addition to a high smoking prevalence in men, biomass smoke exposure is almost uniform in this population. With a life expectancy of 52 years, COPD represents a major threat to men and women of all ages in rural areas of Uganda.