PT - JOURNAL ARTICLE AU - Laura Neves AU - Adriana Chiappa AU - Vinicius da Silva AU - Paulo Vieira AU - Gerson Cipriano, Jr AU - Ross Arena AU - Alexandre Dias AU - Gaspar Chiappa TI - Comparative effects of inspiratory muscle training and resistance training on respiratory and skeletal muscle strength in COPD: Responses of the a pulmonary rehabilitation program DP - 2014 Sep 01 TA - European Respiratory Journal PG - P598 VI - 44 IP - Suppl 58 4099 - http://erj.ersjournals.com/content/44/Suppl_58/P598.short 4100 - http://erj.ersjournals.com/content/44/Suppl_58/P598.full SO - Eur Respir J2014 Sep 01; 44 AB - Background: We tested the hypothesis that inspiratory muscle training (IMT) is more effective than resistance training (RT) in improving exercise capacity, inspiratory fraction (IF), maximal respiratory muscle strength and lower limb muscle force production in Chronic Obstructive Pulmonary Disease (COPD) patients. Methods: Patients were assigned to a 6-month program of IMT (n=51), RT (n=53) or control (usual care, n=50). Pulmonary function, inspiratory and expiratory muscle strength (PImax and PEmax), exercise capacity by oxygen uptake (peak VO2) and 6-minute walk distance (6-MWT), and quadriceps muscle torque (QMT) and endurance (QME) were evaluated. Results: RT significantly increased forced vital capacity (65 ±10 vs. 71 ± 9 % pred), PEmax (63 ± 14 vs. 127± 31 cm H2O), peak QMT (1.71 ± 0.21 vs. 2.02 ± 0.32 N.m) and QME (127 ± 38 vs. 189 ± 39 kg.max rep) compared with IMT and controls. In contrast, IMT increased PImax (IMT, 53 ± 15 vs. 125 ± 24 cm H2O), and IF (28.4 ± 9.7 vs. 30.3 ± 9.1 % pred) compared with RT. Both IMT and RT similarly increased peak VO2 (IMT, before 18.5 ± 4.5; after, 21.1± 3.8 ml.kg-1.min-1; RT, before, 19.7 ± 5.6; after, 20.5± 4.3 ml.kg-1.min-1; p <0.01) and 6-MWT distance (IMT, before 387 ± 98; after, 461 ±96 m; RT, before, 391±79; after, 460 ± 91 m; p < 0.01). Conclusions: Our study demonstrated that IMT as well as RT significantly increased respiratory and peripheral skeletal muscle performance in COPD patients.