PT - JOURNAL ARTICLE AU - Balam Er Dedekarginoglu AU - Elif Kupeli AU - Nilufer Bayraktar AU - Ersin Ogus AU - Gaye Ulubay TI - The role of inflammatory biomarkers and health related quality of life questionnaires in distinction of exacerbation and stable chronic obstructive pulmonary diseases DP - 2014 Sep 01 TA - European Respiratory Journal PG - P575 VI - 44 IP - Suppl 58 4099 - http://erj.ersjournals.com/content/44/Suppl_58/P575.short 4100 - http://erj.ersjournals.com/content/44/Suppl_58/P575.full SO - Eur Respir J2014 Sep 01; 44 AB - COPD is a preventable and treatable disease which is characterized by recurrent symptoms and exacerbations. Exacerbation diagnosis is established by according to patients' history and subjective symptoms. Although there is not any objective and definite parameters for diagnosis, emerging physical examination findings and inflammatory biomarkers can mostly be a guide in clinical practice.In our study, we aimed to demonstrate the benefit of COPD Assessment Test (CAT) scores to diagnose exacerbation of COPD.With this purpose, all COPD patients(n=53, M/F=40/13, mean±SD age= 68,6±1,1years) who was admitted to our hospital at the time of exacerbation were included in the study. The CAT score and inflammatory biomarkers of the patients were compared in both exacerbation period(EP) and stable period(SP) to evaluate whether CAT score of COPD patients could diagnose EP or not. We also examined the correlation between CAT score and, IL-6), CRP and SF-36 score of the patients.The CAT score of the patients in SP was lower than in EP (mean ±CAT exacerbation=23,2±1,7 and mean±CATstable=15,0±1,0)(p<0,01). Likewise there was an improvement in SF-36 physical health scores in SP when compared with EP(p<0,05). The CAT score was correlated with IL-6(p=0,01), CRP(p= 0,01) and leucocytes(p=0,03) in the EP. No correlation has been found between the CAT scores in SP and the number of hospital admissions in the last one year due to exacerbations(p=0,02).We suggested that, CAT could be a useful questionnaire to diagnose exacerbation of COPD regarding to its correlation with inflammatory biomarkers like CRP and IL-6.