RT Journal Article SR Electronic T1 Occupational COPD among Danish women – A population-based study JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP 3207 VO 44 IS Suppl 58 A1 Else Toft Würtz A1 Tine Halsen Malling A1 Vivi Schlünssen A1 Jens Georg Hansen A1 Charlotte Brasch Andersen A1 Øyvind Omland YR 2014 UL http://erj.ersjournals.com/content/44/Suppl_58/3207.abstract AB AIMTo analyse for occupational COPD among women aged 45-84 in the cross-sectional North Jutland COPD Prevention Study.METHODThe subjects were recruited from 155 general practitioners from two Danish counties in 2004-06. The women accounted for 37% of the age and sex stratified sampling, and 1636 women were recruited. 10 were excluded due to prior lung cancer. COPD was defined as FEV1/ FVC z-score <2.5 standard deviations and FEV1 z-score <2. Smoking habits and occupational history was obtained by questionnaire. The Danish version of The International Standard Classification of Occupations (DISCO-88) and expert derived assessment was used to select jobs with exposure to vapour, gas, dust (organic and inorganic), and fume (VGDF). Low exposure was defined as 0-4 years in a job, medium 5-14 years, and high ≥ 15 years. Smoking was grouped in 0-<10, 10-20, and >20 smoked pack-years.RESULTSOf 372 DISCO-88 codes 72 were identified with VGDF exposure. Occupational exposure to VGDF were stated in 17% (n=279) in between 1 and 3 jobs. Organic dust exposure was the dominating (83%). The age standardised COPD prevalence was 4.6% (n=76). Trend analyses showed a dose-response association between VGDF or organic dust exposure and COPD, both p=0.02. Exposures were dichotomised as ever or never exposed subjects. Adjusted for smoking, increased risk of COPD was found for subjects exposed to VGDF OR 2.08 (95% CI 1.16-3.73) and organic dust OR 2.31 (95% CI 1.24-4.33). Excluding 174 women with prior self-reported asthma increased both associations; VGDF OR 2.89 (95% CI 1.41-5.91) and organic dust OR 3.31 (95% CI 1.56-7.05).CONCLUSIONThe risk for COPD was increased among women exposed to occupational VGDF and solely organic dust exposure.