TY - JOUR T1 - Comparison of physiological impairment in ILD patients with and without diagnostic IPF features JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - P3757 AU - Beatrice Anne Marie Downie AU - Joanna Shakespeare AU - Lynsey Archer AU - Robert Hastings AU - Felix Woodhead AU - Emma Helm AU - Rhian Hughes AU - David Parr Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/P3757.abstract N2 - IntroductionPhysiological impairment correlates with outcome in interstitial lung diseases (ILD), which is known to be worse in patients with idiopathic pulmonary fibrosis (IPF), but the role of cardiopulmonary exercise testing (CPET) is less well established than pulmonary function tests.ObjectivesTo compare physiological impairment in ILD patients with and without diagnostic features of IPF using static lung function, incremental shuttle walk and CPET.Methods46 patients were recruited from a specialist ILD clinic. Disease classification into 'IPF' or 'not diagnostic of IPF' (nd-IPF) using the ATS/ERS 2011 guidelines was achieved by MDT consensus (Raghu, G. et al. Am J Respir Crit Care Med, 2011; 183(6):788-824).Comparison of resting and exercise parameter means was with Mann-Whitney, Chi-squared, Fisher's exact and unpaired t-tests.Results24 patients were designated IPF and 22 as nd-IPF. The IPF group was 92% male, and the nd-IPF group was 54% male (p = 0.0065). RV (% predicted) was higher in the nd-IPF group (47% vs. 38%, p = 0.02), but there were no other significant differences.All IPF patients and 19 nd-IPF patients reached anaerobic threshold (AT). The ventilatory equivalent for carbon dioxide (VE/VC02) at AT in the IPF group was 38.12 compared with 34.23 in the nd-IPF group (p = 0.057).ConclusionDespite differences in the prognosis of these ILD subgroups, our data shows similar physiology at presentation. This suggests a common pathophysiological mechanism and, possibly, a common symptom threshold that leads to clinical presentation. ER -