TY - JOUR T1 - Effect of ADRB2 gene polymorphism on treatment outcomes in asthmatics: Cold airway hyperresponsiveness and asthma control JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - P4778 AU - Denis Naumov AU - Juliy Perelman AU - Victor Kolosov AU - Dinara Ivanoshchuk AU - Vladimir Maksimov AU - Mikhail Voevoda AU - Svetlana Naryshkina Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/P4778.abstract N2 - Single nucleotide polymorphisms (SNP) of β2-adrenergic receptors gene (ADRB2) may influence the efficacy of bronchial asthma (BA) maintenance therapy. Cold airway hyperresponsiveness (CAH) is also affected by ADRB2 SNP and may complicate achievement of BA control.The aim of the present study was to assess the role of the ADRB2 SNP in determining the treatment response in terms of CAH and BA control in patients living in cold climate.Methods. 60 persistent asthmatics aged 39±1,32 with poor BA control (scored 14,4±0,42 on ACT) underwent spirometry before and 3-minutes after isocapnic cold air (-20°C) hyperventilation (ICAH), control assessment with ACT questionnaire and ADRB2:c.46A>G (rs1042713) SNP genotyping. Observation was made before and after 6 months of maintenance therapy.Results. In this study association of the ADRB2 SNP with CAH was repeatedly confirmed (45% vs. 15% for 46AA and 46GG genotypes, respectively, p<0.01). ICAH-provoked ΔFEV1 also differs significantly between 46AA and 46GG genotype carriers (−13.6±3.28% vs. −3.6±1.19% respectively, p=0.001). After the treatment CAH decreased in all patients but ADRB2 46GG carriers and no significant difference in ΔFEV1 was observed any longer (−6.8±1.99% vs. −2.9±1.02% for ADRB2 46AA and 46GG genotypes, respectively, p>0.05). Initially, BA control was independent from genotype (p>0.05). However, by the end of the treatment 46AA patients had lower control in comparison to 46GG homozygous subjects (17.1±1.07 vs 20.0±0.54, respectively; p=0.025).Conclusions. ADRB2 46AA genotype predisposes to worse treatment response in BA patients living in cold climate, at least in part due to its association with CAH. ER -