PT  - JOURNAL ARTICLE
AU  - Natalie Dean
AU  - David Parr
AU  - Joanna Shakespeare
TI  - Late-breaking abstract: The impact of global lung initiative (GLI) implementation in a cohort of patients over the age of 70 years
DP  - 2014 Sep 01
TA  - European Respiratory Journal
PG  - P4259
VI  - 44
IP  - Suppl 58
4099  - http://erj.ersjournals.com/content/44/Suppl_58/P4259.short
4100  - http://erj.ersjournals.com/content/44/Suppl_58/P4259.full
SO  - Eur Respir J2014 Sep 01; 44
AB  - The Global Lung Initiative released new "All-Age" multi-ethnic reference ranges for spirometry in 2012 to replace ESCS/ERS ranges. We evaluated the potential impact of using GLI reference equations on an unselected patient cohort over the age of 70 years attending for screening spirometry.Data from 251 patients (132 (53%) male) between January and August 2013 were retrospectively analysed and comparison made between GLI and ESCS reference ranges.View this table:Predicted values for spirometric indices using the ESCS/ERS and GLI 2012 reference equations.GLI reference values were higher than ESCS; 105 and 106 patients had abnormal values, respectively.These differences could reflect changing population demographics and different selection criteria for the reference populations used. The use of GLI did not appreciably alter clinical interpretation in our patients but the impact of GLI on the definition of physiological normality remains uncertain. Therefore, further studies are needed to quantify the potential for changes in disease prevalence estimates and consequent healthcare costs.