@article {CarvalhoP607, author = {Celso R.F. Carvalho and Felipe A.R. Mendes and Andrezza Fran{\c c}a-Pinto and Rafael Stelmach and Alberto Cukier and Milton Martins}, title = {The effect of acute exercise on the systemic inflammation in patients with moderate or severe asthma}, volume = {44}, number = {Suppl 58}, elocation-id = {P607}, year = {2014}, publisher = {European Respiratory Society}, abstract = {Background: Acute exercise modulates the immune response in healthy individuals; however, it effect on asthmatic patients remains unknown. Objective: To evaluate the effects of an acute high intensity exercise on systemic inflammatory mediators in patients. Methods: Thirty-nine patients with moderate or severe asthma under medical treatment and clinically stable (\<30days without exacerbation) were included (42{\textpm}10 years, FEV1=76.8{\textpm} 21.4\% predicted). All patients were submitted to one bout of at high intensity exercise (80\% of VO2max) in a treadmill. A venous blood was collected at rest, immediately after and one hour after the exercise and serum cytokines (interleukin-5 (IL-5), IL-6, IL-8 and IL-10) were measured by using cytometric beat array method (BD Biosciences, CA, USA). Results: Immediately after the exercise bout, asthmatic patients demonstrated a significant increase in plasma cytokines compared to rest IL-5 (246{\textpm}308 vs. 95{\textpm}104 fg.mL-1), IL-6 (449{\textpm}559 vs. 194{\textpm}196 fg.mL-1), IL-8 (3.3{\textpm}1.6 vs. 1.8{\textpm}1 pg.mL-1) and IL-10 (102{\textpm}83 vs. 38{\textpm}62 fg.mL-1) (p\<0.05 for all). One hour after the exercise, inflammatory cytokines (IL-5, IL-6, IL-8) levels returned to rest levels (p\>0.05); however, the levels of IL-10, an anti-inflammatory cytokine, remained at higher levels compared with rest values (81{\textpm}92 vs. 38{\textpm}62 fg.mL-1,p\<0.05). Conclusion: One bout of high intensity exercise induced a persistent increase in the levels of anti-inflammatory cytokine and a transitory increase in the pro-inflammatory cytokines. These results reinforce the relevance of exercise to modulate inflammation in asthmatic patients.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/44/Suppl_58/P607}, eprint = {https://erj.ersjournals.com/content}, journal = {European Respiratory Journal} }