TY - JOUR T1 - Pulse wave velocity in patients with COPD comorbid with arterial hypertension JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - P534 AU - Tatiana Aksenova AU - Vladimir Gorbunov AU - Svetlana Tsarenok AU - Lyudmila Gagarkina Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/P534.abstract N2 - To evaluate the performance of arterial stiffness in patients with COPD and arterial hypertension.58 patients with a mean age of 57.6±6.3 years were examined. The patients were divided into 3 groups: group 1, n=20, patients with combination of hypertension and COPD; group 2, n=20, patients with hypertension; group 3, n=18, patients with COPD. The groups were similar in for age, sex, duration of hypertension and COPD. Applanation tonometry and pulse wave velocity were made by SphygmoCor.Patients of group 1 showed the improvement of central systolic blood pressure in compassion with group 2 (131.8±4.8 mmHg vs 120.9±8.4 mmHg, p=0.047) and compared to a group 3 (96.8±9.7 mmHg, p=0.000042). Patients with a combination of hypertension and COPD had elevated central pulse pressure of 46.8±4.1 mmHg vs 34.4±9.6 mmHg in group with isolated hypertension (p=0.0002) and against 28.3±8.5 mmHg in group with isolated COPD (p=0.0029). In patients with hypertension and COPD, Pulse Wave Velocity (PWV) in the carotid-femoral segment was 11.2±0.5 m/sec vs 6.9±1.6 m/sec (p=0.00002) and it was 7.3±1.4 m/sec (p=0.0064) in patients with isolated hypertension and COPD. PWV was strongly correlated with the presence of COPD (γ=0.58, p=0.000023) and hypertension (γ=0,34, p=0.0025) by Gamma correlation method. The combination of hypertension and COPD (β=0.42, p=0.00019), age (β=0.39, p=0.0002) and the level of aortic pulse pressure (β=0.54, p=0.001) were marked as independent factors of PWV increasing according to multiple regression analysis.The presence of COPD in patients with hypertension leads to an increasing of arterial stiffness. ER -