PT - JOURNAL ARTICLE AU - Jinming Liu AU - Haijian Liu AU - Wenlan Yang AU - Shujuan Chen TI - Chronotropic incompetence and its relation to exercise intolerance in chronic obstructive pulmonary disease DP - 2014 Sep 01 TA - European Respiratory Journal PG - P4884 VI - 44 IP - Suppl 58 4099 - http://erj.ersjournals.com/content/44/Suppl_58/P4884.short 4100 - http://erj.ersjournals.com/content/44/Suppl_58/P4884.full SO - Eur Respir J2014 Sep 01; 44 AB - RATIONALE Chronic obstructive pulmonary disease (COPD) is a major health problem.Chronotropic incompetence (CI) is the inability to proportionally increase heart rate (HR) to meet increases in metabolic demand. The objectives of this study were to determine whether there is an association between disease severity and CI.METHODS Arterial blood gas analysis (ABG), Pulmonary lung function test(PFT) and Cardiopulmonary exercise testing(CPET) were tested in 60 patients with stable COPD and 45 healthy volunteers, based on chronotropic response index, COPD patients were divided into normal chronotropic group(n=23)and chronotropic incompetence group(n=37).RESULTS Chronotropic incompetence was present in 61.7% of the patients with COPD, exercise capacity (peak oxygen uptake as percentage of predicted value, peak VO2%pred) ,peak HR,and chronotropic response index significantly lower than controls in patients with COPD, restingHR significantly higher than controls. Compared with normal chronotropic group, FEV1%pred and exercise capacity decreased more significantly in chronotropic incompetence group. chronotropic response index was significant associated with FEV1%pred and peak VO2%pred.multivariate regression analysis shows chronotropic response index and FEV1%pred were independent predictors of exercise capacity in patients with COPD. A cutoff of 0.74 for the chronotropic response index showed a specificity of 94.1% in predicting patients with a peak VO2%pred<60%.CONCLUSIONS In patients with COPD the degree of disease severity is associated with chronotropic response index, chronotropic incompetence represents an important determinant of exercise capacity in COPD patients.