TY - JOUR T1 - Severity of airway obstruction in overweight/obese patients with chronic obstructive pulmonary disease(COPD) JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - P3972 AU - Daniel Vaz AU - Daniel Coutinho AU - Maria João Oliveira AU - Margarida Dias AU - Manuela Vanzeller AU - Maria Céu Brito AU - Teresa Shiang Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/P3972.abstract N2 - IntroductionIn COPD the prevalence of overweight/obesity can reach 54% and is associated with altered respiratory function.Aims and objectivesDetermine the prevalence of overweight/obesity in a population of COPD patients and its impact in lung function and number of exacerbations.MethodsAge, gender, smoking habits, GOLD stage,body mass index (BMI), waist perimeter (WP), lung function parameters and number of exacerbations per year were characterized in a group of 30 COPD patients.ResultsMean age was 67±12 years, 76,7% were male, and 83,3% had smoking habits. 13,3% were classified as GOLD A, 3,3% as GOLD B, 30% as GOLD C and 30% as GOLD D. Overall prevalence of overweight/obesity was 53,3% according to BMI≥25 kg/m2 and 66,7% according to WP≥94 cm for men and ≥80 cm for women. Patients with BMI≥25 kg/m2 had higher values for percent predicted of FEV1-%FEV1- (49,9%vs32,8%;p=0,0038) and of peak expiratory flow-PEF-(55,6%vs40,5%;p=0,043); a trend for higher percent predicted of forced vital capacity-FVC (73,2%vs65%;p=0,46) was observed. Patients with a WP defining central obesityhad higher values of %FEV1(49%vs27%;p=0,005), of PEF(56,7%vs31,4%;p=0,001) and of FVC(77,9%vs50,9%;p=0,027). Number of exacerbations per year was not different between overweight and non-overweight patients(2,4vs2;p=0,3 if BMI≥25 kg/m2; 2,2vs,2,1;p=0,8 if WP defining central obesity).ConclusionsIn this population of predominantly GOLD C and GOLD D COPD patients, those who are overweight/obese have a less severe grade of obstruction compared with non-overweight patients, suggesting a reverse epidemiology relationship between overweight/obesity and severity of airway obstruction. ER -