@article {BisenovaP2555, author = {Nelya Bisenova and Aigerim Yergalieva}, title = {Monitoring of antimicrobial resistance respiratory strains of streptococcus pneumoniae}, volume = {44}, number = {Suppl 58}, elocation-id = {P2555}, year = {2014}, publisher = {European Respiratory Society}, abstract = {Objectives: Microbiological screening of respiratory infections establishes the possible change of pathogens, as well as their resistance rate. The aim of this study was definition three-year dynamics of resistant strains of Streptococcus pneumoniae, isolated from patients with community-acquired pneumonia (CAP). Methods: A total of 153 strains isolated from respiratory specimens collected from 106 hospitalized patients diagnosed with CAP at National Scientific Medical Research Center during 2010 {\textendash} 2012 were included to the study. The identification of isolates and antibiotics susceptibility testing were performed by VITEK 2 (bioMerieux) automated system. Results: The study of etiological structure of sputum showed that Streptococcus pneumoniae was the most common pathogen, detection significantly increased from 35.2\% in 2010 to 45.0\% in 2012 (p\<0.05). The results showed a tendency to increase the resistance strains of Streptococcus pneumoniae during this period. The highest increasing percentage of resistance was observed to macrolides: to clarithromycin from 42.8\% in 2010 to 60.0\% in 2012, to erythtomycin from 40.0\% to 51.8\%, to azithromycin from 39.4\% to 59.0\% respectively. Resistance to penicillin increased from 28.0\% to 37.0\%, to ciprofloxacin from 22.7\% to 36.3\%. The lowest increasing percentage of resistance of Streptococcus pneumoniae was to ceftriaxone from 9.0\% in 2010 to 15.0\% in 2012 and to levofloxacin from 13.0\% to 20.0\% respectively. No resistance was observed to vancomycin. Conclusion: To reduce the resistance of Streptococcus pneumoniae necessary rational use of antibiotics and requires constant microbiological monitoring.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/44/Suppl_58/P2555}, eprint = {https://erj.ersjournals.com/content}, journal = {European Respiratory Journal} }