PT  - JOURNAL ARTICLE
AU  - Sung-Kyoung Kim
AU  - Chan Kwon Park
AU  - Ki Hoon Park
AU  - Ju Sang Kim
AU  - Joong Hyun Ahn
AU  - Soon Seog Kwon
AU  - Chi Hong Kim
TI  - Clinical analysis of 32 cases of biopsy-proven secondary organizing pneumonia following community-acquired pneumonia
DP  - 2014 Sep 01
TA  - European Respiratory Journal
PG  - P3760
VI  - 44
IP  - Suppl 58
4099  - http://erj.ersjournals.com/content/44/Suppl_58/P3760.short
4100  - http://erj.ersjournals.com/content/44/Suppl_58/P3760.full
SO  - Eur Respir J2014 Sep 01; 44
AB  - Objective: To analysis the clinical characteristics of biopsy-proven secondary organizing pneumonia (SOP) during treatment for community-acquired pneumonia (CAP). Method: Among patients admitted with CAP as an initial diagnosis, 32 patients of biopsy-proven SOP during treatment were reviewed retrospectively. Results: There were 30 males and 2 females, with a mean age of 64.93±13.37 years. Initial computed tomography (CT) findings were as follows: lobar consolidation (n=12), patchy consolidation (n=10), mass-like consolidation (n=5), nodular consolidation (n=4), and bronchopneumonic infiltration (n=1). These lesions were combined with ground glass opacity (GGO) in 24 cases, including 8 cases of extensive GGO. All 5 cases of mass-like consolidation showed perilesional GGO. All patients showed good clinical course (defervescence, decreased WBC count and CRP level, and radiologic improvement) in early several days. However, there was no further radiologic improvement from hospital day (HD) 8.56±4.73 and, biopsy was performed on HD 9.52±4.54. Steroid was added on antibiotic therapy with pathologic confirmation, and follow-up X-ray showed gradual improvement. There was no relapse in follow-up X-ray on 3 months later after treatment completion. Conclusion: SOP should be included in differential diagnosis of no further improvement on serial radiologic follow-up despite of defervescence and decreased WBC count and CRP level during CAP treatment, especially if initial CT findings show consolidation combined with GGO or mass-like consolidation with perilesional GGO. For more clear clarification of SOP, further prospective study of large scale is required.