RT Journal Article
SR Electronic
T1 The effects of adding non-invasive positive pressure ventilation to supplemental oxygen during exercise training in severe COPD: A randomized controlled study
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P3042
VO 44
IS Suppl 58
A1 Senay Tuncel
A1 Alev Gurgun
A1 Hale Karapolat
A1 Hatice Uluer
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/P3042.abstract
AB Aims and ObjectivesWe evaluated the effects of Non-Invasive Positive Pressure Ventilation and supplemental oxygen (PR+NIPPV+O2, supplemental oxygen during PR (PR+O2) in comparison with only Pulmonary Rehabilitation (PR) on lung functions, blood gases, lactate levels, respiratory muscle pressures, dyspnea, walking distances, quality of life and depression in patients with severe COPD.MethodsThirty-five patients (mean±SD age, 65.4±6.5 y) with a mean FEV1 of 39.4±7% predicted, undergoing an 8 week outpatient PR were randomized to either PR+NIPPV+O2 or PR+O2 or PR groups. The patients were assessed at baseline and after the intervention.ResultsThe average inspiratory and expiratory pressures were 12.0±1.5 cmH20 and 5.1±0.8 cmH20, respectively. In PR+NIPPV+O2 group, RV and TLC decreased (-305.0±489.1 and -325.0±524.8, both p=0.05, respectively). Although there was an increase in FVC in PR group, no significant change was found in PR+O2 patients. The increases in Pimax were (13.5±12.1 cmH20, p=0.003) in PR+NIPPV+O2and (8.7±9.8 cmH20, p=0.02) in PR group. There was no decrease in lactate levels. The increases in walking tests were greater in PR+NIPPV+O2 group (69.8±53.2 m in 6MWT and 66.6±65.2 m in ISWT, p=0.001 and p=0.005, respectively) than PR+O2 group (42.5+55.5 m in 6MWT and 53.5+70.2 m in ISWT, p=0.01 each, respectively). Dyspnea and depression improvement was achieved only in PR+NIPPV+O2 and the total score of SGRQ improved in PR+O2 patients.ConclusionNIPPV added to supplemental oxygen during PR was associated with better physiological adaptations than other modalities.