RT Journal Article
SR Electronic
T1 A meta-analysis of health related quality of life (HRQOL) in non-cystic fibrosis bronchiectasis (NCFB): Association with clinical outcomes
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P2571
VO 44
IS Suppl 58
A1 Arietta Spinou
A1 Konstantinos C. Frangos
A1 Rachel Garrod
A1 Surinder S. Birring
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/P2571.abstract
AB Introduction: HRQOL is impaired in NCFB; however its relationship with other clinical outcomes is poorly understood.Aims: To evaluate the association between HRQOL and clinical outcomes in NCFB.Methods: A search was conducted on Embase, Pubmed, Medline, PsychINFO and Cochrane Library. Studies were included if they reported correlation coefficients for HRQOL with other clinical outcomes. Quantitative analysis used a random effects model and applied Fishers z. Statistical heterogeneity was estimated.Results: Search identified 392 studies and 17 studies (5 abstracts) were included.View this table:Meta-analysis results.Conclusions: Findings supported that HRQOL has a stronger association with functional and symptoms assessments than with objective measures. The review involved heterogeneity of the HRQOL questionnaires and disease aetiologies. These results could form the basis for investigating aetiological relationships in future studies.