TY - JOUR T1 - Prognostic affect of the chronic obstructive pulmonary disease on the local-advanced stage non-small cell lung cancer JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - P2751 AU - Fatma Yildirim AU - Murat Türk AU - Ahmet Selim Yurdakul AU - Can Öztürk Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/P2751.abstract N2 - Aim:In this study,we aimed to investigate the association of chronic obstructive pulmonary disease (COPD) with locally-advanced stage non-small cell lung cancer (NSCLC) in term of frequency, gender distribution, tumor histology, and its effect on the survival of patients.Materials and Methods:Files of 350 patients with stage III and IV NSCLC were retrospectively analyzed. Patient demographic characteristics, smoking habits, ECOG status, time of diagnosis, TNM stage, tumor histological types, pulmonary function test (PFT) values, presence of COPD, treatment and survival of them were recorded.Results:Total 137 patients with the mean age of 63 ± 10 were included. 118 (86.1%) of them were male, 19 (13.9%) were female. 20 (14.6%) patients had stage IIIA, 27 (19.7%) had stage IIIB, 90 (65.7%) had stage IV. Sixty-one (44.6%) patients had COPD at the time of diagnosis. There was no difference between groups with COPD and without COPD in terms of age, gender, tumor histology and treatment modalities (p>0.05). The amount of smoking was higher in the COPD group (p=0.028). There was no difference between the groups with COPD nad without COPD in terms of survival that was investigated with Kaplan-meier curves and log-rank test (p=0.445). When it was evaluated with logistic regression analysis, the presence of distant metastase was detected as a factor affecting the prognosis (p=0.008), but the presence of COPD was not significant factor affecting the prognosis (p=0.543).Conclusion:In patients with locally-advanced NSCLC, the presence of COPD hasn't been identified as a factor affecting the prognosis of patients. ER -