RT Journal Article
SR Electronic
T1 Prevalence of nontuberculosis mycobacterial in patients with bronchiectasis: A meta-analysis
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P2490
VO 44
IS Suppl 58
A1 Haiqing Chu
A1 Lan Zhao
A1 Heping Xiao
A1 Zhemin Zhang
A1 Jingbo Zhang
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/P2490.abstract
AB Background:Nontuberculous mycobacteria (NTM) have emerged as critical opportunistic pathogens of n lung diseases, recently. Patients with preexisting bronchiectasis are susceptible to NTM. Nevertheless, the data about the geographical difference of NTM prevalence are still not fully understood. Therefore, this study aimed to evaluate the prevalence of NTM in patients with bronchiectasis.Methods: The relevant data of the prevalence of NTM in patients with bronchiectasis were retrieved by searching the main database such as such as PubMed, MEDLINE, Cochrane Library, and EMBASE. This Meta-analysis was performed by using Rev. Man 5.1 and Stata11.0 software. The collected information of NTM prevalence was chosen as the effect size.Results:The results of meta-analysis showed that the overall prevalence of NTM was 9.3% in patients with bronchiectasis. The further stratification of subgroup analysis indicated that the combined prevalence of NTM were higher in studies which sample size were more than or equal to 100, in studies which time of study were after or equal to 2002, in studies which participants geographic location were Asian and in studies which method of study were retrospective as well, compared with corresponding groups.Conclusions: Our finding suggested that the prevalence NTM infection is high in patients with bronchiectasis. Though we advise clinicians to apply anti-NTM therapy in patients with bronchiectasis, a larger number of definitive randomized trials are still need to assess this research issue.