RT Journal Article SR Electronic T1 Viral infection land lung function decline following lung transplantation JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP P3316 VO 44 IS Suppl 58 A1 Kathleen Jahn A1 Peter Grendelmeier A1 John David Aubert A1 Hans Hirsch A1 Daiana Stolz A1 Michael Tamm YR 2014 UL http://erj.ersjournals.com/content/44/Suppl_58/P3316.abstract AB Viral infections are very common in immunocompromised patients. The potential association of viral infection with the development of bronchiolitis obliterans syndrome is under dabate. New diagnostic methods such as viral multiplex PCR allow to better diagnose and characterise viral infections in lung transplant recipients. In this study we evaluated wheter viral infection, documented in the lower respiratory tract are associated with a decline in lung function.From October 2010 till December 2013 236 lung transplant recipients underwent bronchoscopy with BAL with bacterial, fungal, cytological and viral work up including multiplex viral PCR for 13 respiratory viruses.Respiratory viruses were detected in 105 cases ( Rhinovirus 44; RSV 14; Coronavirus 10; Influenza A and B 6; Parainfluenza 6; human Metapneumovirus 3; Adenovirus 1; HSV 7; CMV > 10'000 copies 24). A total of 24 patients experienced an acute decline in FEV1, observed in 14 out of 105 cases with viral infection (13.3%) as compared to 10 out of 131 patients without evidence of viral pathogens ( 7.7%). Documented viruses in the 14 cases were: Entero-/ Rhinovirus 7, Coronavirus 2, Parainfluenza 2, Influenza B 1, hMPV 1, RSV B 1. In two cases there were also bacteria grown (MOTT ; pseudomonas).Three patients with no viral infection but an acute decline in lung function showed bacterial or fungal infection (Staph aureus; enterobacteriaceae, aspergillus).Conclusion: Following lung transplantation an acute drop of lung function is only observed in a minority of cases with documented viral infection in the lower respiratoty tract.