@article {BouloukakiP3280, author = {Izolde Bouloukaki and Katerina Giannadaki and Charalampos Mermigkis and Stylianos Michelakis and Eleni Mauroudi and Violeta Moniaki and Nikolaos Siafakas and Sophia Schiza}, title = {Tiotropium respimat versus HandiHaler to improve sleeping oxygen saturation and sleep quality in COPD}, volume = {44}, number = {Suppl 58}, elocation-id = {P3280}, year = {2014}, publisher = {European Respiratory Society}, abstract = {Introduction: Sleep can be associated with clinically important adverse effects in patients with chronic obstructive pulmonary disease (COPD), such as disordered gas exchange and poor sleep quality. There is a shortage of data of the efficacy of long-acting inhaled anticholinergic agents in improving these adverse effects. We aimed to compare the effect of Tiotropium Respimat Soft Mist Inhaler versus HandiHaler on sleeping arterial oxygen saturation (SaO2) and sleep quality in patients with COPD, 6 months after treatment initiation.Methods: In a randomized, parallel-group trial involving patients with mild to moderate COPD, we compared 6 month treatment with tiotropium Respimat to HandiHaler on sleeping SaO2 and sleep quality. Overnight polysomnography and pulmonary function testing was performed at baseline and 6 month after treatment.Results: A total of 361 patients with newly diagnosed COPD, for whom inhaled anticholinergic therapy had been recommended, were randomised and 200 patients completed the 6 month trial. At the end of treatment both groups showed significant improvements in minimum SaO2 and percentage of sleep spent below 90\% of SaO2 (TST90) compared to baseline. However, the patients who received Respimat had significantly better TST90 than did the patients receiving handihaler. Sleep disturbance was highly variable in these patients, but duration of sleep stages were significant better in the Respimat group.Conclusion: Sleeping SaO2 can be improved with tiotropium delivered either by the HandiHaler, or via Respimat device. However, the patients who received tiotropium respimat had significantly improved TST90 as well as sleep architecture parameters.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/44/Suppl_58/P3280}, eprint = {https://erj.ersjournals.com/content}, journal = {European Respiratory Journal} }