TY - JOUR T1 - Inspiratory muscle training: Resistance to fatigue and functional outcomes during ehxaustive exercise in healthy human JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - P3536 AU - Marina Segizbaeva AU - Nikolai Timofeev AU - Elena Kur'yanovich AU - Zhanna Donina AU - Nina Aleksandrova Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/P3536.abstract N2 - The aim of this study was to assess the effect of inspiratory muscle training (IMT) on fatigue resistance of diaphragm (D), parasternal (PS), sternocleidomastoid (SCM) and scalene (SC) muscles in healthy human during exhaustive exercise. Daily inspiratory muscle strength training was performed for 3 weeks in 10 male subjects (at a pressure threshold load of 60% from maximal inspiratory pressure (MIP) for the first wk, 70% from MIP for the second wk, and 80% from MIP for the third wk). Before and after IMT, subjects performed an incremental cycle test to exhaustion. Maximal inspiratory pressure and EMG-analysis of D, PS, SCM, and SC muscles served as parameters for inspiratory muscle fatigue assessment. The before-to-after exercise decrease in MIP and centroid frequency (fc) of EMG (D, PS, SCM and SC) power spectrum (P<0.05) was observed in all subjects before IMT intervention. On the contrary, there were no found the before-to-after exercise significant changes in MIP and fc after IMT. The present study found that in healthy subjects, IMT results in significant increase in MIP (+18%), a delay of inspiratory muscle fatigue during exhaustive exercise and a significant improvement in maximal work performance, PWC170 , anaerobic threshold, minute ventilation and its time-volume parameters as well as VO2 and VCO2. We conclude that IMT increases the resistance of D, PS. SCM and SC to fatigue development during high-intensive exercise and these changes seem to improve the maximal work performance in healthy subjects. ER -