RT Journal Article
SR Electronic
T1 Effect of roflumilast on morphological changes in mucous membrane of bronchi in patients with severe chronic obstructive pulmonary disease
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P3618
VO 44
IS Suppl 58
A1 Mykola Ostrovskyy
A1 Iryna Savelikhina
A1 Oleksandr Varunkiv
A1 Mariana Kulynych-Miskiv
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/P3618.abstract
AB Background. COPD is now recognised to be a condition of global importance because of high morbidity and risk of premature death of millions of people. There were performed biopsies of the mucous membrane of the bronchi in 9 people with severe COPD before treatment and after 30 and 180 days treatment with roflumilast . The material of the research was bronchoalveolar lavage and bronchial biopsy materials received on the level of proximal bronchi bifurcation to segmental bronchi during fiberoptic bronchoscopy.Results of the study: At the and of 30-days treatment with roflumilast on the background of COPD maintance therapy, we have identified better results in comparison with the results before treatment. The main signs of improvement in the morpho-functional state of epithelial cells can be considered: moderate hypertrophy of the nucleus, cytoplasm vacuolization reduce, the number of myofibroblasts are reduced, some of them showed signs of degradation. A six-month therapy with the use of roflumilast gave its positive results. In the pathohistological picture of a bronchus mucous membrane there were outlined positive changes in the epithelial tissue as well as in the connective tissue of lamina propria of mucous membrane.Conclusions:After a 180-day treatment with roflumilast on the background of a basic therapy of patients with COPD III there was detected the most positive dymanics of pathohistological picture of a bronchus mucous membrane in the epithelial tissue as well as in the connective tissue of lamina propria of mucous membrane, in comparison with a 30-day treatment.