RT Journal Article SR Electronic T1 Patients with no cystic fibrosis bronchiectasis colonized by pseudomonas aeruginosa: Role of inhaled colistin JF European Respiratory Journal JO Eur Respir J FD European Respiratory Society SP P2472 VO 44 IS Suppl 58 A1 Abel Trujillano Ruiz A1 María Jesús Avilés Inglés A1 María Teresa Antequera Lardón A1 Juan José Franco Miguel A1 María Carmen Abellán Martínez A1 Pedro Méndez Martínez A1 Jose Carlos Vicente López YR 2014 UL http://erj.ersjournals.com/content/44/Suppl_58/P2472.abstract AB ObjectiveTo describe the results of the use of IC in patients with non-cystic fibrosis(CF)bronchiectasis colonized by Pseudomonas aeruginosa in terms of efficiency and quality of life(QOL)Material and MethodRetrospective observational study.Patients who started treatment with IC within a period of 4 years were selected.For each patient we collected demographic,clinical and microbiological data evaluating whether the colonization was initial,intermittent or chronic.At the end of the treatment,efficacy was determined by examining the negative cultures and QOL according to the use of antibiotics and hospitalizations pre and post treatment as well as the adverse effectsResults58 patients who began treatment with IC with an average age of 70±15,4 years were included,43,1% were women.Regarding the type of colonization in 20 patients was initial,in 5 was intermittent and in 24 was chronic.At the time of data collection,32 patients had completed the treatment of which 11 defaulted(9 by adverse reactions and 2 for difficulty in handling the device).The average duration of treatment was 4,5±4 months and 17 negativized the cultures(9 with initial colonization,1 with intermittent and 7 with chronic).The average number of admissions before treatment was 2,5±2,2 versus 0,6±0,9 post-treatment.The average number of antibiotics that took previously to IC was 4,4±3,8 being 1,3±1,6 post-treatmentConclusionsThe proportion of patients who negativized cultures with initial colonization is relevant(45%),thus concluding that early initiation improves efficiencyThe reduction of antibiotic use and hospital admissions along with few adverse reactions,demonstrate the improvement in QOL of patients.