PT - JOURNAL ARTICLE AU - Frederike Kruse AU - Bjoern E. Kleibrink AU - Thomas Rabis AU - Yi Wang AU - Gerhard Weinreich AU - Markus Kamler AU - Helmut Teschler AU - Urte Sommerwerck TI - Quality of life and exercise capacity in lung transplant recipients with and without sleep-disordered breathing DP - 2014 Sep 01 TA - European Respiratory Journal PG - P2198 VI - 44 IP - Suppl 58 4099 - http://erj.ersjournals.com/content/44/Suppl_58/P2198.short 4100 - http://erj.ersjournals.com/content/44/Suppl_58/P2198.full SO - Eur Respir J2014 Sep 01; 44 AB - BackgroundThe prevalence of sleep disordered breathing (SDB) is high in patients after lung transplantation (LTX). It is well-established that SDB is associated with decreased health related quality of life (HRQL). In contrast, findings of SDB impact on exercise capacity (EC) are conflicting. This study therefore aimed to compare HRQL and EC in LTX patients with and without SDB.MethodsFull in-lab polysomnography (PSG) was performed in 53 stable LTX recipients (≥6 months after LTX) according to AASM standards. We compared the non-SDB group (apnea-hypopnea index(AHI)<10/h) with the SDB group (AHI≥10/h) including CPAP-naïve patients at the time of PSG on their HRQL and EC. To assess HRQL we used the Short-Form 36 questionnaire(SF36). Submaximal EC was measured by using the 6-minute walk test(6MWT) and maximal EC was determined by incremental cardiopulmonary exercise testing (CPE). The SDB group included 28 patients (20 male, age 56.4±9yrs, BMI 26.9±3.6kg/m², AHI 32.4±23.1/h) and the non-SDB group 25 patients (11 male, age 52±12yrs, BMI 23.9±4.38kg/m², AHI 4.6±2.7/h).ResultsThere was a negative correlation between AHI and sleep efficiency (r=-0.23, p=0.02). No significant correlation was found between the AHI and sleep efficiency and the 6MWT. In CPE Pmax predicted correlated inversely with the AHI (r=-0.2, p=0.04). Peak O2 uptake predicted correlated inversely with the AHI (r=-0.3, p=0.03) and positively with sleep efficiency (r=0.2, p=0.08). In general, SF36 domains did not differ between SDB and non-SDB patients.ConclusionSDB in LTX recipients is associated with a diminished maximal EC. In patients with and without SDB we found no meaningful difference in HRQL measures.