@article {KovtunP2179, author = {Lyudmila Kovtun}, title = {Interrelation between individual susceptibility to hypoxia and susceptibility to cold before and after cold acclimation}, volume = {44}, number = {Suppl 58}, elocation-id = {P2179}, year = {2014}, publisher = {European Respiratory Society}, abstract = {Aims. There is large individual variability of susceptibility to hypoxia as well as to cold. In low-temperature conditions ventilation controller is influenced by conflicting demand: ventilation should be simultaneously increased to provide oxygen demand and decreased to reduce heat losses. The aim of this study was to define interrelation between susceptibility to hypoxia (HS) and cold (CS) before and after cold acclimation (CA).Methods. 24 healthy men aged 17-24 were tested. HS was estimated as hemoglobin saturation slope during hypoxic test before and after cold exposures (nude, at 13oC, 2 h daily, for 10 days). CS was determined on rectal temperature change during first cold exposure.Results. 3 factors model of Analysis of variances (MANOVA) were used. HS and CS have had 3 levels: 1 {\textendash} high, 2- middle and 3 - low susceptibility and repeat measures - before and after cold acclimation.As shown on Fig. more dramatic changes of hypoxic susceptibility occurred in group with low susceptibility to cold.Conclusions. Susceptibility to hypoxia and susceptibility to cold are independent variables. Cold acclimation is not effective for individuals with low susceptibility to cold and hypoxia. Susceptibility to hypoxia significantly decreased after CA for individuals with low susceptibility to cold but initially high susceptibility to hypoxia. Cold exposure training would be highly effective for them.}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/44/Suppl_58/P2179}, eprint = {https://erj.ersjournals.com/content}, journal = {European Respiratory Journal} }