RT Journal Article
SR Electronic
T1 Efficacy of carbocystein as add-on therapy for adults with light to moderate occupational COPD
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P1122
VO 44
IS Suppl 58
A1 Olyga Vasilyeva
A1 Andrey Gusakov
A1 Natalya Kravchenko
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/P1122.abstract
AB Background The main symptoms of COPD are dyspnoe, cough and phlegm production. GOLD 2014 recommends to include carbocystein as a mucoregulative drug in treatment patients with severe COPD. Carbocystein (CS)is a mucolytic drug, which reduces the viscosity of sputum. Undoubtedly it can be useful for elimination of dust particles and relieving the symptoms of COPD caused by gas, vapors and toxic agents. In this study we compared basis therapy (BT) alone and use of CS as addition to BT in order to evaluate the combined effect in patients with light to moderate COPD, still working in dusty trades.Methods 46 patients with light to moderate COPD, who used LABA and muscarinic receptor antagonist, were submitted to medical examination, questionnaire (SWORD), MRC and CAT score scales and dynamics of sputum expectoration, spirography (measuring FVC, FEV1, FEV1/FVC) before and after the addition therapy with CS (2,7 mg per day) during 30 days. 20 patients received BT alone.Results There were no dynamic of CAT score in BT group but 29 patients (63%) in CS group move from moderate to low impact by CAT score. About 20% (9 patients) move from MRC1 to MRC0 group after 30 days with CS therapy. In CS group we observed positive dynamic of FEV, but it was no statistically significant. Also we note positive dynamics of FEV1/FVC ratio at the end of 20 days with CS in 13% (6 patients). 14 patients (30.4%) fell reduction in the intensity of coughing and improvement expectoration of phlegm.Conclusion Our data suggest that Carbocystein is rather effective in improving expectoration of sputum and reducing of cough intensity in patients with light to moderate COPD due to work-related dust particles.