PT - JOURNAL ARTICLE AU - Kenji Yazaki AU - Naoko Kamada AU - Kenichi Asakura AU - Rei Oba AU - Etsuko Sato AU - Mitsuko Sato AU - Tazuko Sato AU - Kenji Kikuchi TI - Characteristics of pulmonary function of COPD with and without arterial pulmonary hypertension DP - 2014 Sep 01 TA - European Respiratory Journal PG - P3595 VI - 44 IP - Suppl 58 4099 - http://erj.ersjournals.com/content/44/Suppl_58/P3595.short 4100 - http://erj.ersjournals.com/content/44/Suppl_58/P3595.full SO - Eur Respir J2014 Sep 01; 44 AB - Patients with low levels of diffusing capacity of the lung for carbon monoxide (Dlco) do not always have pulmonary arterial hypertension (PAH) as part of chronic obstructive pulmonary disease (COPD).The aim of this study is to investigate the characteristics of pulmonary function of COPD with and without PAH and compare ratios of vital capacity (VC), forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), or inspiratory capacity (IC) to Dlco versus alveolar volume (Dlco/VA)All subjects who needed oxygen therapy and also underwent lung function testing and Doppler echocardiography were reviewed, retrospectively, from September 1, 2011, to January 31, 2014. Fifteen subjects, all ex-smokers, were included(80.6±6.6 age, FEV1 % 41.16±13.15%, FEV1 %predicted 49.14±19.61%, Dlco 5.00±2.83ml/min/mmHg). PAH was defined as the estimated systolic pulmonary arterial pressure (sPAP)≥40mmHg at rest and a diagnosis of PAH by cardiologists. There was no heart failure among any of the subjects with PAH.Six subjects had PAH. In the non-PAH group, Dlco was 4.94±1.40 ml/min/mmHg, and Dlco/VAwas 1.12±0.41 ml/min/mmHg/L. In the PAH group, Dlco was 5.08±4.38 ml/min/mmHg, and Dlco/VA was 0.95±0.59 ml/min/mmHg/L. There were no significant differences between non-PAH and PAH. In the ratio of average PAH to non-PAH, VC/Dlco/VAwas 1.91, FVC/Dlco/VA was 1.87, FEV1/Dlco/VA was 2.01, and IC/Dlco/VA was 2.13. All subjects in the PAH group were significantly correlated with sPAP(r=0.771, 0.771, 0.942, and 0.829, respectively, p<0.05).This report suggests that VC/Dlco/VA, FVC/Dlco/VA, FEV1/Dlco/VA, and IC/Dlco/VA might be useful to assist in diagnosing PAH in COPD.