TY - JOUR T1 - Recruitment maneuvers in the presence of pulmonary hypertension: Cardiorespiratory effects during experimental acute lung injury JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - P2156 AU - Camille Doras AU - Morgan Le Guen AU - Ferenc Peták AU - Walid Habre Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/P2156.abstract N2 - Background- Recruitment maneuvers (RM) are meant to restore alveolar surface for gas exchange. However pulmonary hypertension (PHT) and acute lung injury (ALI) may compromise the respiratory efficiency of RM and worsen their hemodynamic effects.Objectives- To evaluate how the presence of PHT and ALI affects cardiorespiratory functions during RMMethods- Control and crotaline-induced PHT rabbits were anesthetized and mechanically ventilated (positive end expiratory pressure PEEP 3 cmH2O, target tidal volume 6 mL/kg). Forced oscillatory respiratory mechanics, systemic and right ventricular hemodynamics and blood gas analysis were assessed before and after RM (27 cmH2O above PEEP for 5 s, 3 times every 10 s), under basal conditions and following the induction of ALI by repeated lung lavages.Results- Table summarizes cardiorespiratory changes induced by RM. Whereas RM worsened the effect of PHT on the right ventricular end diastolic pressure, neither cardiac index nor stroke work were compromised. RM improved significantly elastance and arterial carbon dioxide (PaCO2) in all groups and conditions, except in control ALI animals. In the latter, RM significantly decreased venous oxygen saturation (SvO2).Conclusion- RM did not affect cardiac work and output regardless of conditions. Moreover in concomitant ALI, PHT somehow counteracted the deleterious effects of RM on elastance and SvO2. ER -