PT  - JOURNAL ARTICLE
AU  - Tetyana Kireeva
AU  - Tetyana Pertseva
AU  - Kseniia Bielosludtseva
AU  - Svitlana Volkova
TI  - Clinical and laboratory predictors of survival in patients with severe community-acquired pneumonia (CAP)
DP  - 2014 Sep 01
TA  - European Respiratory Journal
PG  - P2521
VI  - 44
IP  - Suppl 58
4099  - http://erj.ersjournals.com/content/44/Suppl_58/P2521.short
4100  - http://erj.ersjournals.com/content/44/Suppl_58/P2521.full
SO  - Eur Respir J2014 Sep 01; 44
AB  - Objectives: to determine the significance of different clinical, inflammatory (procalcitonin (PCT) and C-reactive protein (CRP)), immunological (CD4, CD8) markers as predictors of survival in patients with severe CAP.Methods: 51 patients with verified severe CAP without HIV (age – 57,50±4,31 years, men – 37 (72,5%),women – 14 (27,5%)). General analysis, SMRT-CO count, determination of serum PCT and CRP, blood CD4, CD8 prior antibacterial therapy (ABT) (visit 1), on 8–10 day of ABT (visit 2) with count of delta (v 2-1), statistic including factor loading.Results: in 6 (11,7%) patients with severe CAP, despite adequate ABT, lethal end of disease was determined. Statistical value on survival of different parameters is present in table (maximum is 1)View this table:Factor loading of different parameters in patients with severe CAP.Conclusions: 1) initial SMRT-CO count cannot serve as a predictor of survival in patients with severe CAP; 2) feature of survival predicting in patients with severe CAP is the complex account of immune and inflammatory markers; 3) the most significant laboratory predictors of outcome in patients with severe CAP is individual dynamic of CD4 and PCT.