TY - JOUR T1 - Body shape in childhood and adolescence is associated with productive cough in adulthood JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - 428 AU - Marie Waatevik AU - Francisco Real AU - Tomas Eagan AU - Bryndis Benediktsdottir AU - Randi Bertelsen AU - Lennart Bråbäck AU - Thorarinn Gislason AU - Christer Janson AU - Rain Jögi AU - Eva Lindberg AU - Ferenc Macsali AU - Lars Modig AU - Ernst Omenaas AU - Eirunn Saure AU - Vivi Schlünssen AU - Cecilie Svanes AU - Kjell Toren AU - Julia Dratva AU - Ane Johannessen Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/428.abstract N2 - Background: Little is known about how body shapes in childhood and adolescence is associated with respiratory symptoms later in life.Aim: To examine associations between body-shapes in childhood and adolescence and productive cough in adulthood.Methods: In the Respiratory Health in Northern Europe (RHINE) III (2010-12) 12860 subjects aged 38-65, answered questionnaires on respiratory symptoms and self-perceived body shapes at 8 years and at puberty. The 9 body shapes were divided in categories “underweight”, “normal weight” and “overweight”.Associations of productive cough with body shapes were analysed with logistic regressions adjusted for gender, age, environmental tobacco exposure (ETS), education, childhood asthma and current BMI. We ran stratified analyses by smoking habits and gender.Results: 16% of the subjects reported productive cough. Productive cough was significantly more common in those with childhood underweight OR 1.2(1.1,1.5 95%CI) in never-smokers. After additional stratification by gender the association remained significant for women OR 1.3(1.0,1.7 95%CI), but not for men OR 1.3(0.9,1.6 95%CI).There was a significant association between productive cough and puberty overweight in ever-smoking men OR 1.6(1.0,2.5 95%CI), and a border-line significant association in ever-smoking women OR 1.5(0.9,2.5 95%CI).Conclusion: Childhood underweight was associated with productive cough in adulthood for never-smokers. Puberty overweight was associated with adult productive cough for ever-smokers. Metabolic development in childhood and adolescence should be investigated to improve understanding of COPD phenotypes. ER -