TY - JOUR T1 - Physical function and ability, ADL, and health-related QOL of COPD patients with specific exercise tolerance JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - P1294 AU - Jun Horie AU - Shojiro Egoshi AU - Kouichiro Takahashi AU - Shin-ichiro Hayashi Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/P1294.abstract N2 - IntroductionAlthough a large number of previous studies reported a positive correlation between the respiratory function and exercise tolerance, such a finding is frequently inconsistent with those from daily medical services.ObjectiveTo compare the physical function and ability, ADL, and health-related QOL between patients with a favorable respiratory function and poor exercise tolerance and those with a poor respiratory function and favorable exercise tolerance, while defining them as ″patients with specific exercise tolerance″.MethodsAmong 165 COPD patients, 21 showing a %FEV1 of 50% or more and ISWD of 250 m or less (poor-specific group) and 47 showing a %FEV1 of less than 50% and ISWD of 251 m or more (favorable-specific group) were studied.On measurement, %FEV1 and ISWD were used as the main indices, and the BMI, %FVC, FEV1%, IC, percentages of predicted maximum expiratory (%MEP) and inspiratory (%MIP) pressures, hand grip/body weight ratio, strength of the quadriceps femoris muscle (%GP and %QF), duration of one-leg standing, maximum walking speed, 6MWD, Timed up go time (TUG), Nagasaki University Respiratory ADL Questionnaire (NRADL), and SGRQ scores were used as explanatory indices.ResultsIn the poor-specific group, %FVC (p<0.01) and FEV1% (p<0.01) were significantly higher, while %MIP (p<0.01), %GP (p<0.01), %QF (p<0.01), the duration of one-leg standing (p<0.01), TUG (p<0.01) , maximum walking speed (p<0.01), 6MWD (p<0.01), and NRADL scores (p<0.01) were significantly lower.ConclusionIt may be possible to maintain the physical function and ability, as well as ADL, by training to maintain exercise tolerance even in advanced cases with a poor respiratory function. ER -