RT Journal Article
SR Electronic
T1 Longitudinal relationship between disease specific quality of life and asthma control in children
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP P1175
VO 44
IS Suppl 58
A1 Dillys van Vliet
A1 Brigitte Essers
A1 Bjorn Winkens
A1 Jan Heynens
A1 Jean Muris
A1 Quirijn Jöbsis
A1 Edward Dompeling
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/P1175.abstract
AB RationaleManaging chronic paediatric asthma includes optimizing both asthma control and asthma-specific quality of life (QoL). However, it is unknown to what extent asthma-specific QoL is related to asthma control or other clinical asthma characteristics over time.ObjectivesTo determine in children, longitudinally:1) the association between asthma control and disease specific QoL;2) the relationship between clinical asthma characteristics and disease specific QoL.MethodsA prospective cohort study in 96 asthmatic children was carried out over one year. During two monthly regular visits, disease specific QoL, asthma control, dynamic lung function indices, fractional exhaled nitric oxide, occurrence of exacerbations, and use of rescue medication were assessed. Association between asthma clinical characteristics and asthma-specific QoL was analysed using linear mixed models.ResultsAsthma control improvement was associated with an increase in the PAQLQ total score (p-value (estimate); <0.01 (0.43)). The following clinical characteristics were significantly related to a decreased PAQLQ total score: increased use of β2-agonists, occurrence of wheezing episodes in the year before the study, occurrence of an asthma exacerbation in the two months prior to a clinical visit and lung function (FEV1 % predicted value) (p-values ≤ 0.01).ConclusionThere was a strong longitudinal relationship between asthma control and asthma-specific QoL. In addition, increased use of β2-agonists, occurrence of wheezing episodes before the study, occurrence of asthma exacerbations during the study, and decreased lung function were associated with a lower asthma-specific QoL over time.