RT Journal Article
SR Electronic
T1 Plaque-related vs. plaque-unrelated cardio and cerebrovascular events (CCVE) in hospitalized patients with community-acquired pneumonia (CAP): Preliminary results from the FAILCAP study (ClinicalTrials: NCT01143155)
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 485
VO 44
IS Suppl 58
A1 Stefano Aliberti
A1 Letizia Corinna Morlacchi
A1 Fabio Giuliani
A1 Paula Peyrani
A1 Tim Wiemken
A1 Vincenzo Valenti
A1 Lisa Pancini
A1 Antonio Voza
A1 Elena Parazzini
A1 Paolo Rossi
A1 Daiana Stolz
A1 Delfino Legnani
A1 Elena Magni
A1 Luca Richeldi
A1 Riccardo Fantini
A1 Valter Monzani
A1 Roberto Cosentini
A1 Giulia Bonaiti
A1 Giulia Suigo
A1 Paola Faverio
A1 Alberto Pesci
A1 Julio Ramirez
A1 Francesco Blasi
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/485.abstract
AB The development of CCVE in patients with CAP might be influenced by the presence or absence of coronary atherosclerosis. To evaluate the incidence, risk factors and outcomes of hospitalized patients with CAP undergoing plaque-related vs. plaque-unrelated CCVE. An international, multicenter, prospective, observational study was performed on consecutive CAP patients hospitalized from Oct. 2009 to Oct. 2012 in 8 Respiratory Dpts. Among the 905 patients enrolled (59% males; median age: 76 years), the incidence of plaque-related and plaque-unrelated CCVE was 3% and 21% respectively [Table 1]. In-hospital mortality among patients who experienced plaque-related was higher in comparison to both those who experienced plaque-unrelated CCVE and the rest of the population (41% vs. 21% vs. 4%, p<0.001). Similar results were obtained with mortality at 30 days (48% vs. 29% vs. 6%, p<0.001) and re-hospitalization at 30 days (21% vs. 15% vs. 8%, p=0.014). Risk factors independently associated with the presence of CCVEs were age, ventilatory / blood pressure support and PSI Risk Class V. Further interventional trials on cardioprotective medications should be designed comparing patients with plaque-related vs. unrelated events.View this table:Table 1