RT Journal Article
SR Electronic
T1 A randomised controlled trial of CPAP vs non-invasive ventilation for initial treatment of obesity hypoventilation syndrome
JF European Respiratory Journal
JO Eur Respir J
FD European Respiratory Society
SP 4868
VO 44
IS Suppl 58
A1 Mark Howard
A1 Amanda Piper
A1 Bronwyn Stevens
A1 Anne Holland
A1 Brendon Yee
A1 Eli Dabscheck
A1 Duncan Mortimer
A1 Angela Burge
A1 Daniel Flunt
A1 Catherine Buchan
A1 Linda Rautela
A1 Nicole Sheers
A1 David Hillman
A1 David Berlowitz
YR 2014
UL http://erj.ersjournals.com/content/44/Suppl_58/4868.abstract
AB Background Although obesity hypoventilation syndrome (OHS) has become the most common indication for domiciliary Non-Invasive Ventilation (NIV) optimal treatment remains unclear.Methods We undertook a 3 month randomised controlled trial of NIV (spontaneous-timed mode bi-level positive airway pressure – Bi-level PAP) vs CPAP for initial treatment of OHS and evaluated the impact on treatment failure (hospital admission, persistent ventilatory failure or non-compliance), quality of life and control of ventilatory failure.Results 60 participants were randomised (29 Bi-level PAP and 31 CPAP, age 53 y (SD 10), BMI 55 kg/m2 (SD 12), PaCO2 60 mmHg (SD 14)). There was no difference between groups in treatment failure at 3 months (Bi-level PAP, 17.2% vs CPAP, 12.9%, p=0.65). Sleepiness (Epworth Sleepiness Scale (ESS)), quality of life (SF36 and Severe Respiratory Insufficiency questionnaire (SRI)), obesity and ventilatory failure improved in both groups (p<0.01 for all), however there was no difference between groups.View this table:Conclusions CPAP and Bi-level PAP provided similar improvements in symptoms, quality of life and ventilatory failure for OHS after 3 months with no difference in treatment failure.Supported By: The ResMed Foundation.