PT  - JOURNAL ARTICLE
AU  - Svetlana Gumeniuk
AU  - Tatiana Barkhina
AU  - Sergey Polner
AU  - Valentina Golovanova
AU  - Mikhail Gushchin
TI  - Morphofunctional study of bronchial asthma with extrahospital pneumonia
DP  - 2014 Sep 01
TA  - European Respiratory Journal
PG  - P1034
VI  - 44
IP  - Suppl 58
4099  - http://erj.ersjournals.com/content/44/Suppl_58/P1034.short
4100  - http://erj.ersjournals.com/content/44/Suppl_58/P1034.full
SO  - Eur Respir J2014 Sep 01; 44
AB  - Aim: Study of Bronchial Asthma in conjunction with the extrahospital pneumonia of different etiopathogenesis and cell-humoral mechanisms.Materials and methods: 1241 patients were divided into 3 groups: Bronchial Asthma (1), extrahospital pneumonia (2) Bronchial Asthma with extrahospital pneumonia (3). Morphology: cytological and electron-microscopic methods.Results: 7% (86 P) with Bronchial Asthma had extrahospital pneumonia. Divided by severity: mild Bronchial Asthma - 19%, medium level - at 55.8%, and severe degree of Bronchial Asthma - at 24.4%. A coccal flora was found in sputum. In nasal secretions we identified different number of lympho- and granulocytes. The most pronounced changes in the cells were observed in group 3. The surface of the epithelial cells of the upper and lower airways had the identical changes and match clinical data. Intensity changes of ciliated cells correlated with the severity of the diseases. The changes were accompanied by a sharp extrusion of goblet cells, which sometimes formed lacuna.These changes led to severe hypoxic and anoxic amendments to the mucous membranes of the respiratory tract.Conclusion: Epidemiology, clinical and morphological data of patients with combined pathology of inflammatory disorders have more severe cytological and morphological changes in the upper and lower airways. The group 3 of patients needs an individual approach to the treatment and prevention.