TY - JOUR T1 - Aerobic training inhibits bleomycin-induced pulmonary fibrosis in BALB/c mice JF - European Respiratory Journal JO - Eur Respir J VL - 44 IS - Suppl 58 SP - P871 AU - Ana Roberta Almeida-Oliveira AU - Paulo Rogério Pereira AU - Flavia Regina Greiffo AU - Nicole Cristina Rigonato-Oliveira AU - Adilson Andrade-Sousa AU - Jefferson Comin AU - Manoel Oliveira-Junior AU - Ricardo Wesley Custodio AU - Regiane Albertini AU - Ana Paula Ligeiro Oliveira AU - Oliver Eickelberg AU - Rodolfo de Paula Vieira Y1 - 2014/09/01 UR - http://erj.ersjournals.com/content/44/Suppl_58/P871.abstract N2 - Idiopatic pulmonary fibrosis (IPF) is a devastating disease with poor prognostic and no effective treatment is available. Although there are a considerable number of studies showing that pulmonary rehabilitation programs for IPF patients results in improved quality of life and disease management, the possible mechanisms involved in this beneficial effects remains to be elucidated. Therefore, the present study investigated the effects of low intensity treadmill aerobic training in an experimental model of pulmonary fibrosis induced by bleomycin in BALB/c mice. The results show that aerobic exercise reduced the number of total cells and neutrophils in bronchoalveolar lavage (p<0.001), reduced the amount of collagen fibers deposition in airways wall (p<0.01), as well as reduced the levels of IL-1beta, IL-6, KC and TNF-alpha in bronchoalveolar lavage fluid, while increased the levels of anti-inflammatory cytokine IL-10 (p<0.01). We conclude that aerobic training inhibits the fibrotic and inflammatory response in a model of pulmonary fibrosis induced by bleomycin... ER -