@article {Almeida-OliveiraP871, author = {Ana Roberta Almeida-Oliveira and Paulo Rog{\'e}rio Pereira and Flavia Regina Greiffo and Nicole Cristina Rigonato-Oliveira and Adilson Andrade-Sousa and Jefferson Comin and Manoel Oliveira-Junior and Ricardo Wesley Custodio and Regiane Albertini and Ana Paula Ligeiro Oliveira and Oliver Eickelberg and Rodolfo de Paula Vieira}, title = {Aerobic training inhibits bleomycin-induced pulmonary fibrosis in BALB/c mice}, volume = {44}, number = {Suppl 58}, elocation-id = {P871}, year = {2014}, publisher = {European Respiratory Society}, abstract = {Idiopatic pulmonary fibrosis (IPF) is a devastating disease with poor prognostic and no effective treatment is available. Although there are a considerable number of studies showing that pulmonary rehabilitation programs for IPF patients results in improved quality of life and disease management, the possible mechanisms involved in this beneficial effects remains to be elucidated. Therefore, the present study investigated the effects of low intensity treadmill aerobic training in an experimental model of pulmonary fibrosis induced by bleomycin in BALB/c mice. The results show that aerobic exercise reduced the number of total cells and neutrophils in bronchoalveolar lavage (p\<0.001), reduced the amount of collagen fibers deposition in airways wall (p\<0.01), as well as reduced the levels of IL-1beta, IL-6, KC and TNF-alpha in bronchoalveolar lavage fluid, while increased the levels of anti-inflammatory cytokine IL-10 (p\<0.01). We conclude that aerobic training inhibits the fibrotic and inflammatory response in a model of pulmonary fibrosis induced by bleomycin...}, issn = {0903-1936}, URL = {https://erj.ersjournals.com/content/44/Suppl_58/P871}, eprint = {https://erj.ersjournals.com/content}, journal = {European Respiratory Journal} }